New chemo combo aims to beat standard treatment for tough germ cell tumors
NCT ID NCT01873326
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This trial tests whether a new combination of chemotherapy drugs (paclitaxel, ifosfamide, and cisplatin, or TIP) works better than the current standard treatment (bleomycin, etoposide, and cisplatin, or BEP) for people with intermediate- or poor-risk germ cell tumors. These are cancers that start in the testicles or ovaries and are harder to treat. The study enrolls adults with newly diagnosed tumors and measures how well the tumors shrink or disappear after treatment. The goal is to find a more effective option for patients who do not respond well to standard therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- paclitaxel, ifosfamide, cisplatin, mesna, bleomycin, etoposide
- What this could lead to
- If TIP proves more effective, it could become a new standard treatment for hard-to-treat germ cell tumors, improving cure rates.
- What could go wrong
- This is a phase 2 trial with a small number of participants, so results may not be definitive. Both regimens have significant side effects, and TIP may not outperform BEP.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Memorial Sloan Kettering Bergen (Follow-up Only)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
Basking Ridge, New Jersey, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center @ Suffolk
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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Stanford University Medical Center
Stanford, California, 94305-5408, United States
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University of Chicago
Chicago, Illinois, United States
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University of North Carolina
Chapel Hill, North Carolina, 27514, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
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University of Southern California
Los Angeles, California, 90033, United States
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