Fitness test could guide safer stem cell transplants for seniors
NCT ID NCT04761770
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a geriatric assessment—looking at thinking, mobility, mood, nutrition, and medications—can help doctors choose the right transplant intensity for patients aged 60 and older with myeloid blood cancers. The goal is to reduce deaths from transplant complications and improve quality of life. Thirty-three participants will receive a stem cell transplant with a conditioning regimen tailored to their frailty level.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- geriatric assessment and risk-adapted conditioning regimen
- What this could lead to
- If successful, this approach could help doctors personalize transplant intensity for older patients, potentially reducing deaths from transplant complications and improving quality of life.
- What could go wrong
- This is a small, early-phase study (33 participants) without a control group, so results may not apply broadly. The geriatric assessment may not reliably predict outcomes, and transplant still carries serious risks like infection and graft-versus-host disease.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Memorial Sloan Kettering Basking Ridge (Consent Only)
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen (Consent Only)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack (Consent only)
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth (Consent Only)
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (Consent Only)
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester (Consent Only)
Harrison, New York, 10604, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a pill keep blood cancer at bay after a stem cell transplant?
- Can trained immune cells stop blood cancer relapse?
- Could muscle loss predict blood cancer outcomes?
- Can a modified enzyme starve Hard-to-Treat blood cancers?
- Can a Low-Dose antifungal shield vulnerable patients from deadly fungal infections?
- Can a gentler chemo prep make stem cell transplants safer for blood cancer patients?