Immunotherapy plus chemo shows promise for tough hodgkin lymphoma

NCT ID NCT03033914

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy (ABVD) can improve cure rates for people with high-risk Hodgkin lymphoma. About 82 participants with untreated stage III or IV disease are enrolled. The Phase I part checks safety and side effects, while Phase II looks at how well the treatment controls the cancer over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nivolumab (a drug that helps the immune system fight cancer) combined with chemotherapy drugs (doxorubicin, bleomycin, vinblastine, dacarbazine)
What this could lead to: If it works, this could improve the chance of curing high-risk Hodgkin lymphoma and reduce the risk of the cancer coming back.
What could go wrong: This is an early-phase trial (Phase I/II) with a small number of participants, so results may not apply to everyone. There are risks of side effects from both the chemotherapy and nivolumab, including immune-related reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HODGKIN LYMPHOMA

Contacts and locations

Locations

BC Cancer (Data Collection Only)

Vancouver, V5Z4E6, Canada
Hackensack Meridian Health

Hackensack, New Jersey, 07601, United States
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

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