Timing is everything: new study seeks optimal surgery window for rectal cancer

NCT ID NCT00335816

First seen Jan 16, 2026 · Last updated Apr 30, 2026 · Updated 15 times

Summary

This phase 2 trial tests how long patients with stage II or III rectal cancer should wait after chemoradiation before surgery. The goal is to find the best timing to shrink tumors, reduce side effects, and make surgery easier. About 248 participants will receive radiation plus chemotherapy drugs, then have surgery at different intervals to compare outcomes.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cancer Care Center at John Muir Health - Concord Campus

    Concord, California, 94524-4110, United States

  • Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

    Orange, California, 92868, United States

  • City of Hope Medical Center

    Duarte, California, 91010-3000, United States

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio, 44195, United States

  • Colon and Rectal Surgery, Incorporated

    Omaha, Nebraska, 68114, United States

  • H. Lee Moffitt Cancer Center and Research Institute at University of South Florida

    Tampa, Florida, 33612-9497, United States

  • Knight Cancer Institute at Oregon Health and Science University

    Portland, Oregon, 97239-3098, United States

  • Masonic Cancer Center at University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

    St Louis, Missouri, 63110, United States

  • St. Joseph Hospital Regional Cancer Center - Orange

    Orange, California, 92868-3849, United States

  • Tom Baker Cancer Centre - Calgary

    Calgary, Alberta, T2N 4N2, Canada

  • UCSF Helen Diller Family Comprehensive Cancer Center

    San Francisco, California, 94115, United States

  • University of Chicago Cancer Research Center

    Chicago, Illinois, 60637-1470, United States

  • Vermont Cancer Center at University of Vermont

    Burlington, Vermont, 05405-0110, United States

  • Washington Cancer Institute at Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

Conditions

Explore the condition pages connected to this study.