Can a less extensive stomach surgery preserve appetite better?

NCT ID NCT06243757

Ongoing Symptom relief Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study compares two minimally invasive surgeries for cancer at the top of the stomach or where the stomach meets the esophagus: removing only the upper part (proximal gastrectomy) versus removing the entire stomach (total gastrectomy). The goal is to see which approach leads to better appetite and fewer digestive symptoms in the year after surgery. Participants will complete symptom questionnaires before and at several points after their operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: minimally invasive proximal gastrectomy (MIPG) versus minimally invasive total gastrectomy (MITG)
What this could lead to: If one surgery leads to better appetite and fewer symptoms, it could become the preferred option for patients with upper stomach cancer.
What could go wrong: This is a very small pilot study with only 4 participants, so results may not apply broadly. Surgery type is chosen as part of routine care, not randomly assigned.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER GASTROESOPHAGEAL CANCER GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA

Contacts and locations

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Locations

MD Anderson Cancer Center (Data Analysis Only)

Houston, Texas, 77030, United States
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (All protocol activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (All Protocol Activities)

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activites)

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)

Harrison, New York, 10604, United States

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