Liver-Directed chemo may shrink tumors enough for surgery in colorectal cancer
NCT ID NCT00492999
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests whether delivering chemotherapy directly into the liver (hepatic arterial infusion) along with standard IV chemo can shrink inoperable liver tumors from colorectal cancer enough to allow surgical removal. The study involves 64 participants whose cancer has spread only to the liver. The goal is to see how many patients become eligible for liver surgery, which could improve their chances of long-term survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- floxuridine and dexamethasone given directly into the liver artery, plus standard IV chemotherapy
- What this could lead to
- If successful, this approach could make more patients eligible for liver surgery, potentially improving long-term survival for those with colorectal cancer that has spread only to the liver.
- What could go wrong
- This is a mid-stage trial with only 64 participants, so results may not apply broadly. The treatment involves complex procedures and strong chemotherapy, which carry risks like infection, liver damage, and side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Memorial Sloan Kettering Cancer Center
Basking Ridge, New Jersey, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center @ Suffolk
Commack, New York, 11725, United States
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Memorial Sloan Kettering Cancer Center@Phelps Memorial Hospital
Sleepy Hollow, New York, United States
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Memorial Sloan Kettering at Mercy Medical Center
Rockville Centre, New York, United States
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