Liver-Directed chemo may shrink tumors enough for surgery in colorectal cancer
NCT ID NCT00492999
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests whether delivering chemotherapy directly into the liver (hepatic arterial infusion) along with standard IV chemo can shrink inoperable liver tumors from colorectal cancer enough to allow surgical removal. The study involves 64 participants whose cancer has spread only to the liver. The goal is to see how many patients become eligible for liver surgery, which could improve their chances of long-term survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
floxuridine and dexamethasone given directly into the liver artery, plus standard IV chemotherapy
What this could lead to
If successful, this approach could make more patients eligible for liver surgery, potentially improving long-term survival for those with colorectal cancer that has spread only to the liver.
What could go wrong
This is a mid-stage trial with only 64 participants, so results may not apply broadly. The treatment involves complex procedures and strong chemotherapy, which carry risks like infection, liver damage, and side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Memorial Sloan Kettering Cancer Center
Basking Ridge, New Jersey, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center @ Suffolk
Commack, New York, 11725, United States
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Memorial Sloan Kettering Cancer Center@Phelps Memorial Hospital
Sleepy Hollow, New York, United States
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Memorial Sloan Kettering at Mercy Medical Center
Rockville Centre, New York, United States