Could fewer immunotherapy doses work for some melanoma patients? new study investigates.

NCT ID NCT03122522

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a personalized approach to dosing two immunotherapy drugs (ipilimumab and nivolumab) for people with advanced melanoma. Instead of giving everyone four doses, doctors will check after two doses: patients who show early benefit may stop, while those who don't can receive extra doses. The goal is to see if this flexible plan works as well as the standard fixed schedule.

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Conditions

The condition(s) this trial relates to.

melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC MELANOMA

Contacts and locations

Locations

Brigham and Women's Hospital (Data and Specimen Analysis Only)

Boston, Massachusetts, 02115, United States
Columbia University (Data Analysis Only)

New York, New York, 10032, United States
Hartford Healthcare Alliance (Data Collection Only)

Hartford, Connecticut, 06102, United States
Hospital for Special Surgery (Data Analysis)

New York, New York, 10021, United States
JOHNS HOPKINS HOSPITAL (Data Analysis Only)

Baltimore, Maryland, 21287, United States
Jaykumar Thumar

Hartford, Connecticut, 06102, United States
Lehigh Valley Health Network (Data Collection Only)

Allentown, Pennsylvania, 18103, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

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