New dye could replace radioactive tracers in vulvar cancer surgery

NCT ID NCT06127836

Ongoing Diagnosis Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a dye called indocyanine green (ICG) used with near-infrared imaging can find sentinel lymph nodes as well as the standard radioactive tracer method in people with early-stage vulvar cancer. About 22 participants will receive both methods during surgery to see if ICG works just as well. If it does, it could offer a simpler, radiation-free option for guiding surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Indocyanine green (ICG) injection
What this could lead to: If successful, ICG near-infrared imaging could replace the current standard, making sentinel lymph node detection faster and avoiding radioactive tracers.
What could go wrong: This is a small, early-phase study with only 22 participants, so results may not apply to all patients. The technique may not be as accurate as the current method.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

vulva cancer vulvar melanoma vulvar squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VULVAR CANCER

Contacts and locations

Locations

Houston Methodist Cancer Center (Data Collection Only)

Houston, Texas, 77030, United States
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York, 10604, United States

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