Acupuncture needles aim to zap cancer brain fog
NCT ID NCT04007770
First seen Jun 26, 2026 · Last updated Aug 13, 2026 · Updated 3 times
Summary
This phase 2 study tests whether acupuncture can improve memory, focus, and thinking problems (often called 'chemo brain') in people who have had breast, colorectal, prostate, or gynecological cancer. About 48 participants will receive either real acupuncture or sham (fake) acupuncture over 10 weeks. The study measures how much their thinking difficulties change using a standard questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- acupuncture
- What this could lead to
- If it works, this could point toward a drug-free way to help cancer survivors think more clearly and feel less foggy.
- What could go wrong
- This is a small, early-phase pilot study with only 48 people. The sham acupuncture group may also improve, making it hard to tell if real acupuncture is truly better.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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48 people
The number who actually took part.
- Started
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Jul 2019
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * English-speaking * Age 18 ≥ years old * Diagnosis (breast, colorectal, prostate or gynecological cancer) * Completed initial cancer treatment (surgery, chemotherapy, and/or radiation therapy) at least one month prior to study enrollment (patients receiving maintenance cancer treatment with hormonal or targeted therapies are permitted) * Must report moderate or greater perceived CD as indicated by a score of "quite a bit" or "very much" on at least one of the two items that specifically assess concentration (item #20) and memory (item #25) on the EORTC QLQ-C30 instrument (version 3.0) * Must indicate that their cognitive functions have worsened since their cancer diagnosis by replying "Yes" to all of the following questions: * Do you think or feel that your memory or mental ability has gotten worse since your cancer diagnosis? * Do you think your mind isn't as sharp now as it was before your cancer diagnosis? * Do you feel like these problems have made it harder to function on your job or take care of things around the home? * Must be willing to adhere to all study-related procedures, including randomization to one of the 2 possible choices: acupuncture or sham acupuncture Exclusion Criteria: * Active disease * Use of acupuncture for cognitive symptom management within the past 3 months * Diagnosis of Alzheimer's disease, vascular dementia, Parkinson disease, or other organic brain disorder * Score of ≥10 on the Blessed Orientation-Memory-Concentration (BOMC) screening instrument * Primary psychiatric disorder not in remission * Initiation or change in medication (e.g., hypnotics, sedatives, and/or antidepressants) in the past 8 weeks
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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