Immunotherapy plus chemo shows promise for bladder cancer in early trial

NCT ID NCT02989584

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy (gemcitabine and cisplatin) is safe and works better for people with advanced bladder cancer. About 54 participants will receive the combination treatment. The goal is to see if the combo can improve outcomes compared to chemo alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

atezolizumab combined with gemcitabine and cisplatin

What this could lead to

If successful, this could point toward a more effective treatment for advanced bladder cancer by adding immunotherapy to standard chemotherapy.

What could go wrong

This is an early-phase study with only 54 participants, so results may not apply broadly. The combination may cause more side effects than chemo alone, and it's unclear if it will improve survival.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

infiltrating bladder urothelial carcinoma stage IVb bladder cancer transitional cell carcinoma urinary bladder carcinoma Urinary Bladder Neoplasms urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hartford Healthcare Cancer Institute @ Hartford Hospital

    Hartford, Connecticut, 06102, United States

  • Lehigh Valley Health Network

    Allentown, Pennsylvania, 18103, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • New York University

    New York, New York, 10010, United States

  • Ohio State University

    Columbus, Ohio, 43210, United States