New drug duo takes on rare cancer

NCT ID NCT04624178

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This phase 2 study is testing whether combining two drugs, rucaparib and nivolumab, can treat advanced or metastatic leiomyosarcoma (LMS), a rare soft-tissue cancer. The 20 participants take rucaparib pills twice daily and get nivolumab infusions every four weeks. The main goal is to see how many people's tumors shrink or stop growing, compared to standard chemotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rucaparib and nivolumab
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced leiomyosarcoma that has stopped responding to standard chemotherapy.
What could go wrong: This is a small, early-phase trial with only 20 participants, so results may not apply to everyone. The drugs can cause side effects like fatigue, nausea, and immune-related reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

leiomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEIOMYOSARCOMA

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (Limited protocol activities)

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York, 10604, United States

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