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Could less radiation be just as effective for HPV throat cancer?

NCT ID NCT03323463

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) for people with HPV-positive throat cancer. The goal is to reduce long-term side effects while still controlling the cancer. About 316 participants are being enrolled, and the study is currently in Phase 2.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma human papillomavirus-related squamous cell carcinoma oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HPV-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA SQUAMOUS CELL CARCINOMA OF THE NECK

Contacts and locations

Locations

  • Baptist Alliance MCI (Data Collection Only)

    Miami, Florida, 33143, United States

  • Hartford Healthcare (Data Collection)

    Hartford, Connecticut, 06102, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10021, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Rockville Centre

    Rockville Centre, New York, 11570, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.