Glow-in-the-Dark dye could help detect oral cancer

NCT ID NCT03085147

Ongoing Diagnosis Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This study tests a fluorescent dye called PARPi-FL that may make oral cancer cells glow during an endoscopic exam. About 23 people with oral squamous cell carcinoma will gargle the dye before surgery, and doctors will check for safety and how well the dye highlights tumors. It is the first human test of this dye, so the main goals are safety and finding the best dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PARPi-FL (a fluorescent dye)
What this could lead to: If successful, this dye could help doctors spot oral cancers more clearly during routine exams, potentially leading to earlier detection.
What could go wrong: This is an early phase trial with only 23 people, so results may not apply to everyone. The dye might not work well for all tumor types or locations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

oral cavity squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ORAL SQUAMOUS CELL CARCINOMA (OSCC)

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Consent Only)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Consent only)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Consent only)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Consent only)

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk-Commack (Consent only)

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Consent Only)

Harrison, New York, 10604, United States

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