Glow-in-the-Dark dye could help detect oral cancer
NCT ID NCT03085147
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a fluorescent dye called PARPi-FL that may make oral cancer cells glow during an endoscopic exam. About 23 people with oral squamous cell carcinoma will gargle the dye before surgery, and doctors will check for safety and how well the dye highlights tumors. It is the first human test of this dye, so the main goals are safety and finding the best dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PARPi-FL (a fluorescent dye)
What this could lead to
If successful, this dye could help doctors spot oral cancers more clearly during routine exams, potentially leading to earlier detection.
What could go wrong
This is an early phase trial with only 23 people, so results may not apply to everyone. The dye might not work well for all tumor types or locations.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Memorial Sloan Kettering Basking Ridge (Consent Only)
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen (Consent only)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Monmouth (Consent only)
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (Consent only)
Rockville Centre, New York, 11553, United States
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Memorial Sloan Kettering Suffolk-Commack (Consent only)
Commack, New York, 11725, United States
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Memorial Sloan Kettering Westchester (Consent Only)
Harrison, New York, 10604, United States