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Less may be more: testing a gentler neck dissection for oral cancer

NCT ID NCT07726199

Recruiting now Disease control Sponsor: Kolhapur Cancer Centre - Cancer Centers of America Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial compares two types of neck surgery for people with oral cancer that has not spread to lymph nodes. One surgery removes lymph nodes from levels I to IV, while the other removes only levels I to III. The goal is to see whether the less extensive surgery can control cancer just as well while causing fewer side effects like shoulder problems. Participants are randomly assigned to one of the two procedures and followed for cancer recurrence, complications, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Selective neck dissection (levels I-III or I-IV)
What this could lead to
If less extensive surgery works as well, patients may have fewer complications, better shoulder function, and improved quality of life after oral cancer treatment.
What could go wrong
This is a single-center trial with 267 participants, so results may not apply broadly. Removing fewer nodes could increase the risk of cancer recurrence in the neck.

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms Mouth Neoplasms oral cavity squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ORAL SQUAMOUS CELL CARCINOMA (OSCC)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Kolhapur Cancer Centre- Cancer Centers of America

    RECRUITING

    Kolhāpur, Maharashtra, 416234, India

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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