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Less may be more: testing a gentler neck dissection for oral cancer

NCT ID NCT07726199

Disease control Sponsor: Kolhapur Cancer Centre - Cancer Centers of America Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This trial compares two types of neck surgery for people with oral cancer that has not spread to lymph nodes. One surgery removes lymph nodes from levels I to IV, while the other removes only levels I to III. The goal is to see whether the less extensive surgery can control cancer just as well while causing fewer side effects like shoulder problems. Participants are randomly assigned to one of the two procedures and followed for cancer recurrence, complications, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Selective neck dissection (levels I-III or I-IV)
What this could lead to
If less extensive surgery works as well, patients may have fewer complications, better shoulder function, and improved quality of life after oral cancer treatment.
What could go wrong
This is a single-center trial with 267 participants, so results may not apply broadly. Removing fewer nodes could increase the risk of cancer recurrence in the neck.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 267 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged over 21 years will be included. * Histologically proven squamous cell carcinoma of oral cavity will be included * Clinical stage T1-T4, N0, M0 * cN0 neck on clinical examination and imaging (CT/MRI) * American Society of Anesthesiologists (ASA) Physical Status I or II * Understands the protocol * and can give informed consent. Exclusion Criteria: * Recurrent cases * FNAC proven Positive cervical nodes * Patients with history of head and neck radiation therapy treatment * Previous neck surgery or radiotherapy * Previous history of any cancer

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms Mouth Neoplasms oral cavity squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral squamous cell carcinoma (OSCC)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kolhapur Cancer Centre- Cancer Centers of America

    RECRUITING

    Kolhāpur, Maharashtra, 416234, India

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