New PET tracer spots hidden prostate cancer when PSA is low

NCT ID NCT03204123

Ongoing Diagnosis Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests whether a new radioactive tracer called 68Ga-HBED-CC-PSMA can detect prostate cancer that has returned after initial treatment, even when PSA levels are very low and standard scans show nothing. Men with biopsy-proven prostate cancer who have been treated with surgery or radiation and have a rising PSA are eligible. The goal is to see if this PET scan can locate the cancer so doctors can decide on the best next steps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 68Ga-HBED-CC-PSMA (a radioactive tracer for PET scans)
What this could lead to: If successful, this imaging method could help doctors find hidden prostate cancer earlier and guide more precise treatment.
What could go wrong: This is a Phase 2 trial, so the tracer's accuracy and safety are still being evaluated. It may not detect all recurrences, and false positives are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE ADENOCARCINOMA PROSTATE CANCER

Contacts and locations

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Locations

Memorial Sloan Kettering Basking Ridge (Consent only)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Consent only )

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (Consent only)

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Consent only)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Consent only)

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (Consent only)

Harrison, New York, 10604, United States

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