New drug cocktail aims to shorten dangerous low white blood cell period after transplant

NCT ID NCT05130827

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether adding plinabulin to the standard drug pegfilgrastim can shorten the time that white blood cell counts stay dangerously low after a stem cell transplant in people with multiple myeloma. Seventeen participants will receive both drugs right after their transplant. The main goal is to see how many days it takes for their white blood cells to recover, which could lower the risk of serious infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: plinabulin and pegfilgrastim
What this could lead to: If it works, this combination could help multiple myeloma patients recover their white blood cell counts faster after a stem cell transplant, reducing infection risk.
What could go wrong: This is a small, early-phase pilot trial with only 17 participants, so results may not apply broadly. The drugs could also cause side effects like bone pain or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited protocol activities)

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York, 10604, United States

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