Radiation may reboot Cancer-Fighting immune drugs in spreading tumors

NCT ID NCT03693014

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether a precise type of radiation called SBRT can restore the effectiveness of immunotherapy drugs in people whose metastatic cancer has started to progress. About 69 adults with melanoma, lung, bladder, kidney, or head/neck cancers will receive radiation to up to three tumor spots while continuing their FDA-approved checkpoint inhibitor. The goal is to see if this combination can shrink or control non-irradiated tumors without requiring lifelong medication.

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Conditions

The condition(s) this trial relates to.

head and neck cancer kidney cancer lung cancer lung neoplasm melanoma metastatic malignant neoplasm metastatic melanoma Neoplasm Metastasis renal carcinoma renal cell carcinoma urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hartford Healthcare

    Hartford, Connecticut, 06102, United States

  • Lehigh Valley Health Network

    Allentown, Pennsylvania, 18103, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Rockville Centre

    Rockville Centre, New York, 11570, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States