High-Dose cocktail shows promise against new myeloma

NCT ID NCT02937571

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a combination of three drugs—carfilzomib, lenalidomide, and dexamethasone—in 29 people newly diagnosed with multiple myeloma. The goal was to find the safest high dose of carfilzomib and see how well it clears cancer cells from the body. Researchers measured side effects and checked for minimal residual disease (tiny amounts of leftover cancer).

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: carfilzomib, lenalidomide, and dexamethasone
What this could lead to: If successful, this could lead to a more effective initial treatment for multiple myeloma, potentially achieving deeper remission with manageable side effects.
What could go wrong: This is an early-phase study with only 29 participants, so results may not apply to all patients. The high-dose carfilzomib may cause significant side effects, and long-term benefits are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center @ Suffolk

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

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