Personalized chemo boosts CAR T-Cell success in young leukemia patients
NCT ID NCT07223021
First seen Nov 01, 2025 · Last updated Jun 16, 2026 · Updated 32 times
Summary
This study tests whether giving a personalized dose of the chemotherapy drug fludarabine before CAR T-cell therapy can improve outcomes for children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. About 130 participants will be randomly assigned to receive either standard or personalized fludarabine dosing. The goal is to see if the personalized approach extends the time without cancer returning or worsening.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baylor College Medical Center (Data Collection Only)
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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Children's Hospital of Philadelphia (Data Collection Only)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-••••
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Cincinnati Children's Hospital Medical Center (Data Collection Only)
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••
Contact Phone: •••-•••-••••
Contact
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Texas Children's Hospital (Data Collection)
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-••••
Conditions
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