Can surgery and radiation tame spread of HER2+ breast cancer?
NCT ID NCT07053085
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding surgery and targeted radiation to standard treatment helps people with HER2-positive breast cancer that has spread to up to 5 spots in the body. About 178 adults will be randomly assigned to receive either standard care alone or standard care plus surgery and radiation. The goal is to see if the combination delays cancer progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- surgery (lumpectomy or mastectomy) and radiation therapy (locoregional radiation and stereotactic body radiation therapy)
- What this could lead to
- If successful, this approach could become a new standard to control or delay progression of HER2-positive breast cancer that has spread to a few spots in the body.
- What could go wrong
- This is a phase II trial with 178 participants, so results are still preliminary. Adding surgery and radiation may not improve outcomes and could increase side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITINGMontvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (All protocol activites)
RECRUITINGNew York, New York, 10065, United States
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Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITINGMiddletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (Limited protocol activities)
RECRUITINGRockville Centre, New York, 11553, United States
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Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities )
RECRUITINGCommack, New York, 11725, United States
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Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITINGHarrison, New York, 10604, United States
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Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
RECRUITINGBasking Ridge, New Jersey, 07920, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a triple drug combo shrink HER2-Positive breast tumors before surgery?
- Can a Two-Drug attack shrink Hard-to-Treat breast cancer?
- Can an extra radiation dose keep HER2+ breast cancer at bay?
- Can mapping tumor DNA unlock personalized breast cancer care?
- Can a drug cocktail cure metastatic breast cancer? a trial aims to find out
- Can less chemo be enough? a trial challenges standard treatment for HER2-Positive breast cancer