Lung cancer trial combines two treatments to outsmart resistance
NCT ID NCT04410796
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares the standard drug osimertinib alone versus osimertinib plus chemotherapy (carboplatin and pemetrexed) in people with metastatic EGFR-mutant lung cancer who still have detectable cancer DNA in their blood after starting osimertinib. The goal is to see if the combination can delay cancer growth or spread. About 571 participants will be enrolled, and the study is currently recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
osimertinib, carboplatin, and pemetrexed
What this could lead to
If successful, this could provide a more effective treatment option for people with EGFR-mutant lung cancer whose cancer shows signs of resistance to osimertinib alone.
What could go wrong
This is a phase 2 trial, so results are not yet proven. Adding chemotherapy may increase side effects without improving outcomes, and the benefit may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Columbia University (Data Collection Only)
ACTIVE_NOT_RECRUITINGNew York, New York, 10032, United States
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Hackensack Meridian Health
RECRUITINGHackensack, New Jersey, 07601, United States
Contact Phone: •••-•••-••••
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John Hopkins Medical Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Phone: •••-•••-••••
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MD ANDERSON CANCER CENTER (Data Collection Only)
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital (Data Collection Only)
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITINGBasking Ridge, New Jersey, 07920, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITINGMontvale, New Jersey, 07645, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Cancer Center (All protocol activities)
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••
Contact Phone: •••-•••-••••
Contact
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Memorial Sloan Kettering Commack (Limited protocol activities)
RECRUITINGCommack, New York, 11725, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITINGMiddletown, New Jersey, 07748, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITINGUniondale, New York, 11553, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Westchester (Limited protocol activities)
RECRUITINGHarrison, New York, 10604, United States
Contact Phone: •••-•••-••••
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
Contact Phone: •••-•••-••••
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New York University
RECRUITINGNew York, New York, 10010, United States
Contact Phone: •••-•••-••••
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Sarah Cannon Research Institute
RECRUITINGNashville, Tennessee, 37203, United States
Contact Phone: •••-•••-••••
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UC Davis Cancer Center (Data Collection Only)
RECRUITINGSacramento, California, 95817, United States
Contact Phone: •••-•••-••••
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University of California San Francisco
ACTIVE_NOT_RECRUITINGSan Francisco, California, 94143, United States
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University of Washington (Data Collection Only)
RECRUITINGSeattle, Washington, 98109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••