Scientists hunt for genetic clues to predict tiny thyroid tumor growth
NCT ID NCT02363595
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to find out which small thyroid cancers (papillary microcarcinoma) are likely to grow and cause problems. Researchers will analyze genetic and clinical features from 750 adults with these small tumors who are being monitored without immediate treatment. The goal is to better predict disease progression and help guide decisions on whether active surveillance or intervention is needed.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 750 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2014
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All papillary thyroid cancer patients evaluated at MSKCC clinic.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Biopsy proven papillary thyroid cancer (or suspicious for papillary thyroid cancer) confirmed by MSKCC cytopathologist. * Being followed with active surveillance at MSKCC * Biopsied index nodule less than or equal to 2 cm in maximum dimension * Thyroid and neck US performed and interpreted by a MSKCC radiologist within 6 months prior to study entry. Exclusion Criteria: * Biopsied index nodule greater than 2 cm in any dimension * Age less than 18 yrs old
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States