Can extra numbing shots make prostate biopsies hurt less?

NCT ID NCT06986083

Recruiting now Symptom relief Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding local anesthesia (numbing medicine) during a prostate biopsy, while patients are already sedated, reduces pain after the procedure. About 800 men will take part. The goal is to see if this simple change can lower pain scores, cut down on painkiller use, and help people go home sooner.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Local anesthesia (lidocaine or similar)
What this could lead to: If it works, this could make prostate biopsies much less painful and speed up recovery for many men.
What could go wrong: This is a large phase 3 trial, but the benefit may be small or not apply to everyone. Local anesthesia also carries rare risks like allergic reactions or nerve issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Bergen (Consent Only)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center at Basking Ridge (Consent Only)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Consent Only)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk-Commack (Consent only)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Consent Only)
RECRUITING

Harrison, New York, 10604, United States

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