New combo therapy aims to boost CAR t-cell success in hard-to-treat blood cancers

NCT ID NCT04512716

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a radioactive drug (131-I apamistamab) given before CAR T-cell therapy for people with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia or diffuse large B-cell lymphoma. The goal is to find a safe dose and see if the combination is tolerable. Only 12 participants will be enrolled to assess safety and side effects.

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Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia blast phase chronic myelogenous leukemia, BCR-ABL1 positive diffuse large B-cell lymphoma diffuse large B-cell lymphoma activated B-cell type diffuse large B-cell lymphoma germinal center B-cell type high grade B-cell lymphoma hypertrophic pyloric stenosis precursor B-cell acute lymphoblastic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-ALL DIFFUSE LARGE B-CELL LYMPHOMA DLBCL DLBCL ACTIVATED B-CELL TYPE DLBCL GERMINAL CENTER B-CELL TYPE DLBCL UNCLASSIFIABLE DLBCL, NOS GENETIC SUBTYPES DLBCL-CI HGBL HGBL, NOS

Contacts and locations

Locations

Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activites)
RECRUITING

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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