Immunotherapy before Chemo-Radiation shows promise for Hard-to-Treat cancers

NCT ID NCT04165772

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study is testing whether the immunotherapy drug dostarlimab (TSR-042), followed by standard chemoradiation and surgery, can effectively treat advanced mismatch repair deficient (dMMR) solid tumors. About 212 adults with locally advanced dMMR cancers will receive the drug intravenously every 3 weeks, then chemoradiation, and finally surgery. The main goal is to see if the cancer completely disappears or shrinks significantly within 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dostarlimab (TSR-042), capecitabine or 5-FU, and radiation therapy
What this could lead to: If successful, this approach could offer a way to shrink or eliminate advanced dMMR tumors before surgery, potentially reducing the need for more aggressive treatments.
What could go wrong: This is a phase 2 trial, so results are still early. The combination may cause side effects from chemotherapy, radiation, or immunotherapy, and not all patients may respond.

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Conditions

The condition(s) this trial relates to.

endometrial cancer neoplasm rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLINICAL STAGE: STAGE II (T3-4, N-) RECTAL ADENOCARCINOMA SOLID TUMOR SOLID TUMOR, ADULT STAGE III (ANY T, N+)

Contacts and locations

Locations

Baptist Alliance MCI (Data Collection Only)
RECRUITING

Miami, Florida, 33143, United States
Hartford Healthcare (Data Collection)
RECRUITING

Hartford, Connecticut, 06102, United States
Lehigh Valley Health Network (Data Collection Only)
RECRUITING

Allentown, Pennsylvania, 18103, United States
Memorial Sloan Kettering Basking Ridge - Limited Protocol Activities
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen - Limited Protocol Activities
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack - Limited Protocol Activities
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth - Limited Protocol Activities
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau - Limited Protocol Activities
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester - Limited Protocol Activities
RECRUITING

Harrison, New York, 10604, United States

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