New drug combo may shrink tough tumors before standard therapy
NCT ID NCT04165772
First seen Jan 24, 2026 · Last updated Apr 29, 2026 · Updated 15 times
Summary
This study tests whether the drug TSR-042, given before standard chemoradiotherapy and surgery, can improve outcomes for people with advanced mismatch repair deficient (dMMR) solid tumors. About 200 adults with locally advanced disease that hasn't spread will receive the drug, then standard treatment. The main goal is to see if the tumor disappears completely or shrinks significantly within 12 months.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Locations
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Baptist Alliance MCI (Data Collection Only)
RECRUITINGMiami, Florida, 33143, United States
Contact Phone: •••-•••-••••
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Hartford Healthcare (Data Collection)
RECRUITINGHartford, Connecticut, 06102, United States
Contact Phone: •••-•••-••••
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Lehigh Valley Health Network (Data Collection Only)
RECRUITINGAllentown, Pennsylvania, 18103, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Basking Ridge - Limited Protocol Activities
RECRUITINGBasking Ridge, New Jersey, 07920, United States
Contact Phone: •••-•••-••••
Contact
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Memorial Sloan Kettering Bergen - Limited Protocol Activities
RECRUITINGMontvale, New Jersey, 07645, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••
Contact
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Commack - Limited Protocol Activities
RECRUITINGCommack, New York, 11725, United States
Contact
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Monmouth - Limited Protocol Activities
RECRUITINGMiddletown, New Jersey, 07748, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Nassau - Limited Protocol Activities
RECRUITINGUniondale, New York, 11553, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Westchester - Limited Protocol Activities
RECRUITINGHarrison, New York, 10604, United States
Contact Phone: •••-•••-••••
Conditions
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