New drug cocktail targets Hard-to-Treat brain lymphoma

NCT ID NCT07082868

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This early-phase study tests whether combining two drugs, epcoritamab and ibrutinib, is safe for people whose central nervous system lymphoma has come back or not responded to treatment. About 26 adults with this rare cancer will receive the drug combination. The main goal is to find the best dose and watch for side effects.

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Conditions

The condition(s) this trial relates to.

primary central nervous system lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CENTRAL NERVOUS SYSTEM LYMPHOMA PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL) REFRACTORY PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA RELAPSED PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA SECONDARY CENTRAL NERVOUS SYSTEM LYMPHOMA SECONDARY CENTRAL NERVOUS SYSTEM LYMPHOMA (SCNSL)

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States
University of Utah (Data Collection Only)
RECRUITING

Salt Lake City, Utah, 84112, United States

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