Can a cancer drug stop leukemia before it starts?

NCT ID NCT06698003

Recruiting now Prevention Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether the drug mogamulizumab can prevent adult T-cell leukemia/lymphoma (ATL) in people infected with HTLV-1 who are at high risk. About 134 participants will receive low doses of the drug over several weeks. The goal is to see if it can reduce the virus levels in the blood enough to stop cancer from developing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mogamulizumab
What this could lead to: If successful, this could offer a way to prevent a rare but aggressive blood cancer in people carrying the HTLV-1 virus.
What could go wrong: This is a small, early-phase trial (phase 2) with only 134 participants, so results may not apply to everyone. The drug may not reduce viral load enough or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma T lymphoblastic leukemia/lymphoma T-cell leukemia adult T-cell leukemia/lymphoma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA T-CELL LEUKEMIA T-CELL LEUKEMIA/LYMPHOMA T-CELL LEUKEMIA/LYMPHOMA, ADULT

Contacts and locations

Locations

Memorial Sloan Kettering Bergen (All Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (All protocol activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (All protocol activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (All protocol activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (All protocol activities)
RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering at Basking Ridge (All protocol activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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