New hope for lymphoma patients: Chemo-Free treatment shows promise

NCT ID NCT05389293

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This phase 2 trial tests the drug mosunetuzumab, alone or with zanubrutinib, in 152 adults with newly diagnosed follicular lymphoma who need treatment. The goal is to see how many patients achieve complete remission. Participants receive the drug as injections over several months, and those who respond well may stop early.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mosunetuzumab (with or without zanubrutinib)
What this could lead to: If successful, this could provide a new first-line treatment option for follicular lymphoma that may help achieve complete remission without chemotherapy.
What could go wrong: This is an early-phase, single-arm study with no comparison group, so results are uncertain. Side effects from the immune-based therapy are possible, and not all patients may respond.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOLLICULAR LYMPHOMA LYMPHOMA

Contacts and locations

Locations

Georgetown University (Data Collection Only)
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Hackensack Meridian Health (Data collection only)
RECRUITING

Hackensack, New Jersey, 07601, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited protocol activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited protocol activities)
RECRUITING

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk- Commack (Limited protocol activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited protocol activities)
RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering at Basking Ridge Limited Protocol Activities
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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