Could a lower dose of this cancer drug be just as good?

NCT ID NCT03587844

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a lower dose of the drug brentuximab vedotin can still effectively treat three types of skin lymphoma: mycosis fungoides, Sezary syndrome, and lymphomatoid papulosis. The goal is to see if reducing the dose can maintain benefits while possibly lowering side effects. About 58 adults with these conditions are being enrolled to compare different dosing schedules.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brentuximab vedotin
What this could lead to: If successful, this could show that a lower dose of brentuximab vedotin is still effective for these skin lymphomas while causing fewer side effects.
What could go wrong: This is a small Phase 2 trial with only 58 participants, so results may not apply to everyone. Lower doses might also be less effective at controlling the disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LYMPHOMATOID PAPULOSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

lymphomatoid papulosis mycosis fungoides Sezary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMATOID PAPULOSIS MYCOSIS FUNGOIDES SEZARY SYNDROME

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

East White Plains, New York, 10604, United States
Stanford University Medical Center
RECRUITING

Stanford, California, 94305-5408, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.