New cell therapy takes on hard-to-treat brain lymphoma in early trial

NCT ID NCT07137494

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a personalized cell therapy called MB-CART19.1 for people with central nervous system lymphoma (CNSL) that has returned or not responded to prior treatments. The therapy uses the patient's own immune cells, modified to attack the cancer, and is made on-site to speed up delivery. The main goal is to find the safest dose and watch for side effects in about 12 participants.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma of the central nervous system lymphoma primary central nervous system lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY CENTRAL NERVOUS SYSTEM (CNS) LYMPHOMA SECONDARY CENTRAL NERVOUS SYSTEM LYMPHOMA

Contacts and locations

Locations

Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering at Basking Ridge (All Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering at Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering at Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering at Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering at Suffolk-Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering at Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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