New drug duo aims to halt rare cancer's growth

NCT ID NCT06843967

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining two drugs, mirdametinib and palbociclib, can safely slow or stop advanced liposarcoma (a rare soft-tissue cancer). About 54 adults with liposarcoma that has spread or cannot be removed will receive different doses to find the best one. The main goal is to see how long the cancer stays under control.

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Conditions

The condition(s) this trial relates to.

dedifferentiated liposarcoma liposarcoma myxoid liposarcoma pleomorphic liposarcoma round cell liposarcoma well-differentiated liposarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEDIFFERENTIATED LIPOSARCOMA LIPOSARCOMA MYXOID LIPOSARCOMA MYXOID PLEOMORPHIC LIPOSARCOMA PLEOMORPHIC LIPOSARCOMA ROUND CELL LIPOSARCOMA UNRESECTABLE DEDIFFERENTIATED LIPOSARCOMA UNRESECTABLE LIPOSARCOMA WELL DIFFERENTIATED LIPOSARCOMA

Contacts and locations

Locations

Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center Suffolk- Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States

More trials for these conditions

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