New combo attack on brain cancer: early trial launches
NCT ID NCT06934889
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests two experimental drugs, ABBV-637 and ABBV-155, alone or together with ERAS-801 in people whose glioblastoma has come back after standard treatment. About 60 adults with a specific genetic marker (EGFR amplification) will take part. The main goal is to see if the combinations are safe and what side effects they cause.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ABBV-637, ABBV-155, and ERAS-801 (drugs given by IV or mouth)
What this could lead to
If this works, it could point toward a new combination treatment for recurrent glioblastoma, a tough brain cancer.
What could go wrong
This is a very early Phase 1 trial with only 60 people. The main goal is safety, not proof of effectiveness. The drugs may cause side effects or not shrink tumors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Indiana University (Data Collection Only)
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITINGBasking Ridge, New Jersey, 07920, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITINGMontvale, New Jersey, 07645, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••
Contact Phone: •••-•••-••••
Contact
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Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITINGMiddletown, New Jersey, 07748, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITINGRockville Centre, New York, 11553, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
RECRUITINGCommack, New York, 11725, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITINGHarrison, New York, 10604, United States
Contact Phone: •••-•••-••••
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University of California, Los Angeles (Data Collection Only)
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-••••
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University of Miami (Data collection only)
RECRUITINGMiami, Florida, 33136, United States
Contact
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University of Vermont Medical Center
RECRUITINGBurlington, Vermont, 05401, United States
Contact Phone: •••-•••-••••