New combo attack on brain cancer: early trial launches

NCT ID NCT06934889

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests two experimental drugs, ABBV-637 and ABBV-155, alone or together with ERAS-801 in people whose glioblastoma has come back after standard treatment. About 60 adults with a specific genetic marker (EGFR amplification) will take part. The main goal is to see if the combinations are safe and what side effects they cause.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-637, ABBV-155, and ERAS-801 (drugs given by IV or mouth)
What this could lead to: If this works, it could point toward a new combination treatment for recurrent glioblastoma, a tough brain cancer.
What could go wrong: This is a very early Phase 1 trial with only 60 people. The main goal is safety, not proof of effectiveness. The drugs may cause side effects or not shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma gliosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA GLIOSARCOMA

Contacts and locations

Locations

Indiana University (Data Collection Only)
RECRUITING

Indianapolis, Indiana, 46202, United States
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States
University of California, Los Angeles (Data Collection Only)
RECRUITING

Los Angeles, California, 90095, United States
University of Miami (Data collection only)
RECRUITING

Miami, Florida, 33136, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States

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