New hope for hodgkin lymphoma: targeted drug combo shows promise in early trial

NCT ID NCT06377566

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 2 trial is testing whether a combination of drugs called BV-AVD works well for people with newly diagnosed, early-stage bulky Hodgkin lymphoma. The study uses PET scans to guide treatment and includes about 71 participants. The goal is to see if this approach can stop the cancer from growing better than standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Brentuximab vedotin, doxorubicin, vinblastine, dacarbazine, pembrolizumab, gemcitabine, vinorelbine
What this could lead to: If successful, this could offer a more effective treatment option for people with early-stage bulky Hodgkin lymphoma, potentially improving their chances of staying cancer-free.
What could go wrong: This is a small, early-phase (phase 2) trial with only 71 participants, so results may not apply to everyone. The drug combination can cause side effects like nerve damage, low blood counts, and infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HODGKIN LYMPHOMA

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (All Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (All Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States
University of Miami
NOT_YET_RECRUITING

Miami, Florida, 33136, United States

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