Can zapping cancer spots with Super-Precise radiation delay the disease?

NCT ID NCT03808337

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a very focused, high-dose radiation treatment (SBRT) to all visible cancer spots can delay the cancer from getting worse in people with breast or lung cancer that has spread to 1-5 places. About 145 participants will either receive standard care alone or standard care plus SBRT to each metastasis. The goal is to see if the radiation helps keep the disease under control longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Stereotactic body radiotherapy (SBRT) – a precise, high-dose radiation treatment
What this could lead to: If it works, this could show that targeting all visible cancer spots with radiation helps keep the disease from getting worse for longer, potentially improving control of metastatic cancer.
What could go wrong: This is a mid-stage trial with only 145 participants, so results may not apply to everyone. SBRT can cause side effects like fatigue or damage to nearby organs, and it may not improve survival or prevent new metastases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm non-small cell lung carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER METASTATIC NON-SMALL CELL LUNG CARCINOMA NON-SMALL CELL LUNG CANCER TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

Baptist Alliance - McI
RECRUITING

Miami, Florida, 33143, United States
Hartford Healthcare
RECRUITING

Hartford, Connecticut, 06102, United States
Lehigh Valley Health Network
RECRUITING

Allentown, Pennsylvania, 18103, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center @ Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Natera, Inc. (Data and Specimen Analysis Only)
NOT_YET_RECRUITING

San Carlos, California, 94070, United States
WCHN Norwalk Hospital - Data Collection
RECRUITING

Norwalk, Connecticut, 06850, United States

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