New combo therapy aims to stop endometrial cancer return

NCT ID NCT04774419

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 4 times

Summary

This study is for women with a certain type of endometrial cancer (called MMR-D/MSI-H) who have already had surgery. It tests whether adding radiation and an immunotherapy drug called dostarlimab can help keep the cancer from coming back. About 62 participants will receive the combination treatment, and researchers will monitor side effects and how long they stay cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dostarlimab (a drug that helps the immune system fight cancer) and radiation therapy
What this could lead to: If it works, this could offer a new way to reduce the risk of cancer coming back after surgery for women with this specific type of endometrial cancer.
What could go wrong: This is a small, early-phase trial with only 62 participants, so results may not apply to everyone. The combination of radiation and immunotherapy may cause side effects like fatigue or immune reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrium neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (All Protocol Activites)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (All Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (All Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (All Protocol Activities)
RECRUITING

Rockville Centre, New York, 11570, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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