Experimental antibody targets childhood cancers in first human trial
NCT ID NCT04928677
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tests a drug called codrituzumab in children and young adults (ages 1 to 21) whose solid tumors have come back or not responded to treatment and carry a specific protein called GPC3. The main goal is to find a safe dose and see how the body handles the drug. Up to 50 participants will receive weekly IV infusions for 21-day cycles.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
codrituzumab (a lab-made antibody that targets GPC3 protein on tumor cells)
What this could lead to
If it works, this could point toward a treatment for children with certain hard-to-treat solid tumors that have not responded to standard therapy.
What could go wrong
This is a very early Phase 1 trial with only 50 participants, so the main goal is safety, not effectiveness. The drug may not shrink tumors or could cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Healthcare of Atlanta (Data Collection Only)
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Los Angeles (Data Collection Only)
RECRUITINGLos Angeles, California, 90027, United States
Contact Phone: •••-•••-••••
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-••••
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Dana Farber Cancer Institute (Data Collection Only)
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••