GLIOMA

This study tests whether adding the drug abemaciclib to standard chemotherapy (temozolomide) helps children and young adults with a newly diagnosed high-grade glioma live longer without the tumor growing. About 45 participants will receive either the combination or chemo alone af…

This early-phase study tests a modified virus designed to attack brain tumor cells that have come back or grown despite previous treatment. About 62 adults with certain types of brain cancer will receive the virus directly into the tumor, sometimes with a drug to boost the immune…

This study tests a new oncolytic virus (Ad-TD-nsIL12) in 40 adults with high-grade glioma, a fast-growing brain tumor. The virus is designed to infect and kill cancer cells while boosting the immune system. The main goal is to see how many patients survive for at least 12 months …

This early-phase study tests a new drug, DS-1001b, in 47 people with a specific type of brain tumor (glioma) that has an IDH1 mutation and has come back after standard treatments. The main goal is to check the drug's safety and how the body processes it, while also looking for si…

This early-stage trial tests a new drug, BI 764532, in adults with a type of brain tumor (glioma) that has a specific marker called DLL3. The drug is designed to help the body's immune cells recognize and attack the tumor. The main goal is to find the highest safe dose, and parti…

This study tests the drug nivolumab in 62 adults with a type of brain tumor (glioma) that has specific gene changes (IDH mutations). The goal is to see if nivolumab can stop or slow tumor growth. Participants receive the drug through an IV every few weeks and are monitored with s…

This study tests an experimental drug called rhIL-7-hyFc in people with high-grade glioma, a type of brain cancer. The goal is to see if the drug can safely increase the number of infection-fighting white blood cells (lymphocytes) that often drop after standard radiation and chem…

This early-phase study tests an oral drug called LY3410738 in people with advanced solid tumors (like bile duct cancer, bone cancer, or brain tumors) that have certain IDH gene mutations. The main goals are to find the safest dose and see if the drug can shrink tumors or slow the…

This study tests a drug called niraparib in people with two types of brain tumors: newly diagnosed glioblastoma and recurrent IDH-mutant glioma with ATRX loss. The goal is to see if the drug reaches the tumor and slows its growth. Up to 42 participants will receive niraparib befo…

This early-stage trial tests a drug called AZD1390 combined with radiation therapy in people with a fast-growing brain tumor (grade 4 glioma). About 97 participants with either new or returning tumors will receive the drug to see how well it reaches the tumor and if it helps cont…

This early-phase study tests whether adding the experimental drug ruxolitinib to standard brain cancer treatment (radiation and temozolomide) is safe and tolerable for people with newly diagnosed aggressive brain tumors called grade III gliomas or glioblastoma. The study involves…

This early-stage study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The cells are…

This early-stage trial tests a new treatment for people with a severe type of brain cancer (grade 4 glioma) that has come back or not responded to standard therapies. The treatment uses the patient's own immune cells, modified in a lab to target a protein called IL-13Rα2 found on…

This study tests whether the drug pembrolizumab can shrink or stop the growth of a returning brain cancer called malignant glioma in people whose tumors have many genetic mutations. The drug works by activating the immune system to attack cancer cells. The study enrolled 27 adult…

This study tests a special tool called DESI-MS that helps surgeons tell cancerous from healthy brain tissue during an operation. About 285 adults having brain tumor surgery will take part. The goal is to make diagnosis faster and more accurate, which could improve treatment decis…

This study looks at whether a special PET scan using a tracer called [18F]FET can accurately tell the difference between a returning brain tumor (glioma) and harmless changes caused by previous treatment. Researchers will review existing scan data from 400 patients of all ages wh…

This study tests a new type of MRI scan that looks at sodium and other signals in the brain to better understand tumors. It includes healthy volunteers and people with brain tumors (glioma). The goal is to improve how doctors detect and monitor these tumors, which could lead to b…

This study tests whether a non-invasive brain stimulation technique called nrTMS can help people regain movement in their arm or hand after surgery for a brain tumor (glioma). Forty-three patients who have weakness after surgery will receive either real nrTMS or a sham (fake) tre…

This study tests a training program for family members caring for someone with a high-grade glioma. The goal is to see if the training helps reduce caregiver stress, improve caregiving skills, and lessen the patient's symptoms. About 124 pairs of caregivers and patients will take…

This study tests whether a couple-based yoga program can improve quality of life for people with high-grade glioma undergoing radiation therapy and their partners. About 216 couples will participate in Hatha yoga sessions designed to reduce fatigue, distress, and sleep problems. …

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study tests a new MRI technique that tracks how the brain uses sugar (glucose) in people with and without brain tumors (glioma). Researchers will compare the signals from healthy volunteers and patients to see if this method can detect differences in brain metabolism. The go…

This study aims to see if researchers can measure how much of the cancer drug abemaciclib reaches brain tumors in people with aggressive gliomas. Participants take the drug for a few days, then undergo surgery to place a tiny tube in the brain that collects fluid samples for 48 h…

This study looks at people with a type of brain cancer called glioma that has a specific gene change (IDH mutation). Researchers use special MRI scans to measure a substance called 2-HG in the brain over time, which may show when the tumor becomes more aggressive. The goal is to …

This early-phase study tests a new way to take pictures of high-grade gliomas, a type of aggressive brain tumor. The method uses two special dyes to see areas where tumor cells lack oxygen or are growing quickly. Researchers hope this will help them understand why some tumors don…

This study looks at whether it's possible for people with a new brain tumor (glioma) to wear a step counter like a Fitbit during radiation therapy. About 50 patients will wear either a Fitbit or a simple pedometer for 6 weeks. The goal is to see if tracking physical activity can …

This study tests whether a new type of imaging scan can predict how well glioblastoma patients respond to treatment. Ten participants will receive standard care plus an experimental drug called BPM31510. The goal is to see if the scan can forecast survival and tumor progression.