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Promising combo aims to outsmart aggressive brain tumors in kids

NCT ID NCT06413706

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This phase 2 trial tests whether adding the targeted drug abemaciclib to standard chemotherapy (temozolomide) helps children and young adults with newly diagnosed high-grade glioma live longer without their cancer growing. About 45 participants will receive either the combination or chemotherapy alone after radiotherapy. The study lasts about 11 months, with follow-up depending on how the tumor responds.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
abemaciclib (a targeted cancer drug) combined with temozolomide (chemotherapy)
What this could lead to
If successful, this combination could improve how long children and young adults with high-grade glioma live without their cancer growing, compared to standard chemotherapy alone.
What could go wrong
This is a small, early-phase (Phase 2) study with only 45 participants, so results may not apply to everyone. Adding abemaciclib may also increase side effects like fatigue or low blood counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer glioma malignant glioma neoplasm spinal cord neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOMA

Contacts and locations

Locations

  • Azienda Ospedaliera Di Rilievo Nazionale Santobono Pausilipon

    Naples, 80129, Italy

  • Centre Hospitalier Universitaire de Bordeaux Groupe Hospitalier Pellegrin Hopital des Enfants

    Bordeaux, 33076, France

  • Centre Leon Berard

    Lyon, 69008, France

  • Centre de Lutte Contre le Cancer (CLCC) - Centre Oscar Lambret

    Lille, 59020, France

  • Children's Hospital of Orange County - Orange

    Orange, California, 92868, United States

  • Copenhagen University Hospital-Rigshospitalet University Hospital

    Copenhagen, 2100, Denmark

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore

    Rome, 00168, Italy

  • Hopital La Timone

    Marseille, 13885, France

  • Hospital Clinico San Carlos

    Esplugues de Llobregat, 08950, Spain

  • Hospital Infantil Universitario Nino Jesus (HIUNJS)

    Madrid, 28009, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Universitario Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • IRCCS Ospedale Pediatrico Bambino Gesu

    Rome, 00165, Italy

  • Institut Curie

    Paris, 75005, France

  • Institut Gustave Roussy-Gustave Roussy Cancer Center -DITEP

    Villejuif, 94805, France

  • Institutul Oncologic Prof. Dr. Ion Chiricuta

    Cluj-Napoca, 400015, Romania

  • Lucile Packard Children's Hospital (LPCH) - Stanford University

    Palo Alto, California, 94304, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Nagoya University Hospital

    Nagoya, 466-8560, Japan

  • National Center for Child Health and Development (NCCHD)

    Setagaya-Ku Tokyo, 157-8535, Japan

  • Osaka City General Hospital

    Osaka, 534-0021, Japan

  • Perth Children's Hospital

    Nedlands, 6009, Australia

  • Princess Maxima Center for Voor Kinderoncologie B.V

    Utrecht, 3584 CS, Netherlands

  • Queensland Government- Lady Cilento Children's Hospital

    Brisbane, 4101, Australia

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Riley Hospital for Children at Indiana University Health

    Indianapolis, Indiana, 46202, United States

  • The Children's Hospital at Westmead

    Westmead, 2145, Australia

  • The Johns Hopkins Hospital (JHH) - Johns Hopkins Childrens Center

    Baltimore, Maryland, 21287, United States

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UT Southwestern Medical Center Dallas/Childrens Medical Center

    Dallas, Texas, 75235, United States

  • Universitair Ziekenhuis Gent (Uz Gent)

    Ghent, 9000, Belgium

  • Universitair Ziekenhuis Leuven

    Leuven, 3000, Belgium

  • Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur)

    Valencia, 46026, Spain

  • Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc

    Woluwe-Saint-Lambert, 1200, Belgium

  • University of Michigan Health System (UMHS) - C.S. Mott Children's Hospital - Hematology Oncology Clinic

    Ann Arbor, Michigan, 48109, United States

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