Can a pill get into brain tumors? tiny study aims to find out
NCT ID NCT05413304
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tests whether the drug abemaciclib can be measured inside brain tumors after being taken by mouth. One person aged 18–39 with a recurrent high-grade glioma or diffuse midline glioma will take the drug for 4.5 days before surgery. During surgery, a small tube is placed in the brain to collect fluid samples for 48 hours, allowing researchers to see how much drug reaches the tumor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
abemaciclib
What this could lead to
If successful, this could show whether abemaciclib reaches brain tumors effectively, guiding future treatment for these aggressive cancers.
What could go wrong
This is a tiny, early feasibility study with only 1 participant. It cannot prove the drug works, only that drug levels can be measured. Many such studies do not lead to effective treatments.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States