GLIOMA

This early study is testing a new two-step approach for adults with certain brain tumors that are hard to remove completely because they sit in critical brain areas. First, doctors implant a small device to gently stimulate the brain area tied to the tumor, causing a temporary we…

This study is testing a 'prehabilitation' approach for adults with aggressive brain tumors located near the brain's movement control center. Before surgery, participants will either receive standard care, a special physical therapy, or that therapy combined with a non-invasive br…

This study is testing a personalized approach to find treatments for brain tumors that have stopped responding to standard therapies. Doctors will test tumor cells from surgery in a lab to see which drugs might work best for each patient. The goal is to see if this 'drug-matching…

This is a first-in-human study to find a safe dose of an experimental oral drug called GLIX1 for adults with aggressive brain tumors (high-grade glioma or glioblastoma) that have returned or worsened after standard treatments. The main goal is to check the drug's safety and side …

This trial is testing if two already-approved cancer drugs, dabrafenib and trametinib, can help patients with rare cancers or common cancers that have a rare, specific genetic change called a BRAF V600 mutation. The drugs are already used for some cancers like melanoma, but resea…

This early-stage study is testing the safety of a genetically modified herpes virus (M032) designed to fight a rare and aggressive type of brain tumor called diffuse midline glioma. The virus is injected directly into the tumor during surgery in up to 20 children and adults who h…

This early-stage trial is testing a new drug called LMP744 in adults whose aggressive brain cancer (glioblastoma) has returned after standard treatment. The main goal is to see if the drug can shrink tumors and slow the cancer's progression. Participants will receive the drug thr…

This study is testing a new, very fast DNA test that can be used during brain tumor surgery. The goal is to see if leftover cancer cells can be detected while the patient is still on the operating table. If cancer cells are found, surgeons can immediately remove more tissue, whic…

This study is testing whether adding a new oral drug called silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of aggressive brain cancer (glioblastoma) live longer without their cancer getting worse. It will involve about 162 newly diagnosed p…

This study aims to develop a new way to diagnose and monitor brain tumors called gliomas. Researchers will look for specific chemical markers in patients' blood, urine, and tumor tissue to see if they can create a more accurate test. The goal is to improve diagnosis and track the…

This study is testing a new digital camera accessory for a surgical microscope. It aims to help neurosurgeons see suspected aggressive brain tumors more clearly during surgery. The study will observe 37 patients in Europe to see if the new tool provides better image quality and v…

This early-stage study is testing the safety of a new imaging dye called SBK2-ICG. It is given to adults with malignant brain tumors about an hour before their scheduled surgery. The goal is to see if the dye can light up the exact edges of the tumor, helping surgeons remove more…

This study aims to find the best way to close the skin after brain tumor surgery. Researchers will compare two common stitching techniques in 382 adult patients to see which leads to fewer wound problems like infections or leaks. The goal is to improve healing so patients can rec…

This study is testing whether a new type of PET scan (called 18F-AGX PET) can detect early signs of how well the drug Vorasidenib is working in adults with a specific, recurring type of slow-growing brain tumor. The goal is to see if changes on this special scan happen before cha…

This is the first human study of a new, flexible device called the CIPHER System. It will be tested on 10 adults having standard surgery to remove a newly diagnosed brain tumor (glioma). The main goal is to check if the device is safe to use during surgery and to see how well its…

This study aims to see if adding a special camera to a surgical microscope can help surgeons better see and distinguish brain tumor cells during an operation. It will involve 80 adults with suspected high-grade brain tumors who are already scheduled for standard surgery. The rese…

This early study aims to see if a cancer drug (nivolumab) can be made to glow with a special dye, allowing doctors to see exactly where it goes in the brain during surgery for aggressive tumors called high-grade gliomas. The main goals are to check if this glowing version of the …

This study is testing a mobile app called Resilience PRO to see if it can help patients with a specific type of brain tumor (IDH-mutant glioma) better manage their symptoms and quality of life. The app will send weekly surveys to 80 patients to track their symptoms, fatigue, and …