GLIOMA

This early-phase trial tests sitagliptin, a diabetes medicine, combined with standard bevacizumab in 45 adults with recurrent grade 4 glioma (a fast-growing brain cancer). The goal is to find the safest dose and see if the combination can reduce certain immune cells that may help…

This study tests a new approach for people with brain tumors that have not responded to standard treatments. A lab test called pharmacoscopy analyzes a patient's tumor cells to find which drugs might work best for them. The goal is to see if this personalized method is feasible a…

This trial tests two approved drugs, dabrafenib and trametinib, in people with rare cancers that have a BRAF V600 mutation. The drugs are already used for melanoma and lung cancer. About 30 adults, children, and teens will take part. The goal is to see if the drugs shrink tumors …

This early study tests whether a small device placed on the brain can, along with physical therapy, retrain healthy brain areas to take over functions threatened by a tumor. The goal is to allow surgeons to remove more of the tumor without causing permanent weakness or speech pro…

This early-stage trial tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or delay canc…

This study looks at tiny chemical changes on RNA molecules in blood and urine to see if they can help diagnose gliomas, a type of brain tumor. Researchers will test samples from 228 adults scheduled for brain surgery and compare them to healthy controls. The goal is to find a sim…

This early-phase study tests whether a dye called SBK2-ICG can make brain tumor edges glow during surgery, helping surgeons remove the whole tumor while protecting healthy brain. About 12 adults with suspected or confirmed glioma will get the dye before their standard surgery. Th…

This study tests a smartphone app called Resilience PRO to help monitor symptoms and quality of life in 80 adults with IDH-mutated glioma, a type of brain tumor. Participants will answer weekly questionnaires about how they feel and any side effects from their cancer treatment. T…

This study tests a new imaging method to help surgeons see tumor cells during brain surgery for glioma. Researchers will use a special camera to detect a natural substance (protoporphyrin) that glows in tumor tissue. The goal is to see if this technique can improve how completely…

This study tests a new device called CIPHER that helps surgeons map brain activity during tumor removal. Ten adults with newly diagnosed glioma will have the device used on their tumor and surrounding brain tissue during standard surgery. The main goals are to see if the device i…

This study tests a special microscope attachment (GLOW400) that helps surgeons see glowing brain tumors during surgery. About 37 adults with suspected high-grade gliomas will take part. The goal is to check if the tool provides clear images and is safe to use. It is an observatio…

This small study tests whether a brain-training technique called fMRI neurofeedback can help people with glioma (a type of brain tumor) move language-related brain activity away from the tumor area before surgery. Only 4 participants will take part to see if the approach is feasi…

This study tests a new technique that checks for leftover IDH1-mutant tumor cells during brain surgery for glioma. If the test finds any remaining tumor, the surgeon can remove more tissue right away. The goal is to see if this approach helps people live longer without their canc…

This early study tests if a small device can safely collect fluid from the brain during planned surgery for glioma (a type of brain tumor) or epilepsy. Six adults will have the device placed temporarily during their operation. The main goals are to see if the procedure is safe an…

This study looks at whether a special PET scan (18F-AGX) can detect early changes in brain tumors (low-grade IDH-mutant gliomas) during treatment with the drug Vorasidenib. Ten adults with recurrent or residual tumors will receive the drug and undergo both MRI and PET scans over …

This study explores whether physical therapy, alone or combined with brain stimulation, can help the brain reorganize before surgery in adults with high-grade glioma near movement areas. About 63 participants will be randomly assigned to standard care, physical therapy, or physic…