GLIOMA

This early-stage study is testing a personalized treatment for adults with brain glioma who have no other standard options. Doctors take a patient's own tumor-fighting immune cells, grow large numbers of them in a lab, and then infuse them back into the patient. The main goals ar…

This early-stage study is testing a new combination treatment for adults with aggressive brain cancer that has returned after prior therapy. After surgeons remove as much tumor as possible, a modified virus is injected into the area to target remaining cancer cells. The main goal…

This early-stage study is testing whether a special helmet that uses focused ultrasound can safely and temporarily open the blood-brain barrier in adults with glioblastoma. The goal is to help standard chemotherapy drugs reach the brain tumor more effectively. Researchers will en…

This early-stage study is testing whether a radioactive drug called Lutetium-177-PSMA-617 is safe for people with aggressive types of brain cancer called gliomas. The treatment uses a molecule that seeks out and delivers radiation directly to tumor cells that have a specific mark…

This study is testing an oral drug called safusidenib for adults with specific types of brain tumors that have a genetic change called an IDH1 mutation. The main goal is to see if the drug can safely control the tumor and delay its growth or return after standard treatments. The …

This trial is testing if a drug called capmatinib, already used for some lung cancers, can help adults with rare or uncommon cancers that have specific changes in a gene called MET. The goal is to see if the drug shrinks tumors or provides long-term benefit for these hard-to-trea…

This study aims to learn how the drug vorasidenib affects the daily lives and well-being of adults with a specific type of slow-growing brain tumor (IDH-mutant grade 2 glioma) in real-world German clinics. It will follow 150 patients who are already prescribed this drug after sur…

This study is testing whether combining three existing drugs—pembrolizumab, olaparib, and temozolomide—is safe and effective for people whose glioma brain tumor has returned or stopped responding to prior treatment. It aims to see if this combination can better control tumor grow…

This early-stage trial is testing a new oral medication called NST-628 for adults with advanced solid tumors that have specific genetic changes in a key cancer growth pathway. The study aims to find a safe and effective dose and see if the drug can shrink tumors in patients who h…

This study aims to find a safe and effective schedule for delivering a second round of radiation to treat glioblastoma brain tumors that have returned after initial treatment. It will enroll 28 adults whose cancer has come back, testing radiation given four times a week for one, …

This trial is testing if a combination of two drugs, already approved for a type of skin cancer, can help control other rare cancers that share the same genetic change (a BRAF V600 mutation). It aims to enroll 30 adult patients with various rare or uncommon cancers to see if the …

This study is testing whether adding a new experimental medicine called APG-157, taken as dissolving pastilles in the mouth, can help control aggressive brain tumors (high-grade glioma) that have returned after previous treatment. The APG-157 pastilles are given alongside the sta…

This study is for people with a very aggressive type of brain cancer (glioblastoma) who are not well enough for surgery and have a poor outlook. It is testing if a shorter, more intense course of radiation, guided by a special PET scan to target the tumor precisely, can help pati…

This study is testing if methimazole, a drug normally used for thyroid conditions, can help control the growth of glioblastoma, an aggressive brain cancer. Researchers believe the drug might work by boosting the body's natural production of a protective compound called hydrogen s…

This trial is testing if a drug called entrectinib, already approved for some lung cancers, can help control other rare cancers that share the same genetic change (called ROS1-positive). It aims to enroll about 30 adults and children with these rare cancers to see if the drug shr…

This early-stage study is testing whether a personalized combination of four drugs is safe and can help control brain tumors (glioma) that have come back or remain after previous treatment. The trial aims to see if doctors can use regular scans and fluid tests to quickly decide i…

This study is testing the safety of adding a wearable device called Optune to standard radiation and chemotherapy for adults with brainstem gliomas. The device creates low-intensity electric fields that may interfere with cancer cell division. Researchers will monitor 10 patients…

This study is testing whether combining an oral vitamin A-based drug (ATRA) with an immunotherapy (retifanlimab) can help control a specific type of recurrent brain tumor called IDH-mutant glioma. It aims to see if this combination is safe and can stimulate the patient's own immu…

This study is testing a two-step treatment for brain tumors (gliomas) that have come back. First, doctors use a laser to heat and destroy tumor tissue. Then, patients receive a short, intense course of radiation therapy. The goal is to see if this combination can control the tumo…

This early-stage study is testing a new oral medicine called PF-07799933, both alone and combined with other drugs, for people with advanced solid tumors that have a specific BRAF gene change and have stopped responding to standard treatments. The main goals are to find a safe do…

This study is testing whether a specialized form of radiation therapy, called proton therapy, can be carefully delivered to treat brain tumors while avoiding a key memory center in the brain called the hippocampus. The main goal is to see if this 'hippocampal avoidance' approach …

This study is testing if follow-up care for certain rare cancers can be done just as well remotely by a nurse over the phone, compared to traditional in-person visits with a doctor at the hospital. It aims to see if patients stick to their recommended check-up schedule better wit…

This early-stage study is testing a new cell therapy for children and young adults with aggressive or returning brain tumors. Doctors collect a patient's own immune cells, engineer them in a lab to target a protein (B7H3) found on tumor cells, and then deliver these 'CAR T cells'…

This study is testing a new drug called PLX038 for adults with aggressive brain or spinal cord tumors that have returned or progressed. It focuses on tumors with specific genetic changes (MYC or MYCN) that drive cancer growth. The goal is to find a safe dose and see if the drug c…

This early-phase study is testing a new, personalized vaccine called TAMAVAQ for adults with newly diagnosed glioma, a type of brain cancer. The vaccine is custom-made for each patient using their own tumor and advanced computer modeling (AI and quantum mechanics) to try to train…

This early-stage study is testing the safety and initial effects of a new oral medicine, PF-07799544, when taken with another drug, PF-07799933. It is for adults with advanced solid tumors, like melanoma or lung cancer, that have a specific genetic change called a BRAF V600 mutat…

This study is testing whether a mobile app can help deliver and monitor treatment for adults with glioma brain tumors from home. The goal is to improve access to specialized care for patients who live far from major cancer centers or face other barriers. Participants will use the…

This trial is testing whether adding a new drug called tarlatamab to a standard chemotherapy (temozolomide) is safe and can help control aggressive brain tumors. It will enroll about 70 teenagers and adults whose tumors have a specific marker (DLL3) and have stopped responding to…

This study is testing a special type of MRI scan called magnetic resonance elastography (MRE) to see if it can tell the difference between a brain tumor coming back and scar tissue from previous radiation treatment. The goal is to help doctors make more accurate diagnoses and bet…

This study is testing whether a special type of PET scan using a tracer called 18F-fluciclovine can help doctors more accurately tell if a child's aggressive brain tumor is actually growing again or if the changes seen on a regular MRI are just a temporary reaction to treatment. …

This study is testing a new combined PET/MRI brain scan designed to detect a specific genetic mutation (IDH) in gliomas, a common and often aggressive type of brain tumor. The goal is to see if this non-invasive scan can accurately identify the tumor's subtype, which helps doctor…

This study is testing a special type of PET/CT scan to see if it can better find and diagnose tumors in patients with certain conditions, including brain tumors (glioma) and a hormone disorder. Researchers will scan 500 adult patients who are suspected of having or have been trea…

This study is testing a new type of MRI scan, called CEST, to see if it can create better maps of brain tumors. It will be added to standard PET/MRI exams for 800 patients with glioma or brain metastases. The goal is to see if measuring the acidity (pH) inside tumor tissue can he…

This study is testing whether a special type of ultrasound imaging can help brain surgeons see tumor boundaries more clearly during surgery. Researchers want to know if injecting a safe contrast dye and using ultrasound helps distinguish tumor tissue from healthy brain tissue in …

This study is testing whether an artificial intelligence (AI) tool can accurately predict important genetic changes in a type of brain tumor called glioma, using standard microscope images. Researchers will compare the AI's predictions against traditional, more expensive lab test…

This study is testing a new type of MRI scan that uses a special injected substance to create detailed pictures of brain tumors called gliomas. The main goal is to see if this new scan is safe and practical to use. Researchers will also check if the scan can help doctors better s…

This study is testing a new way to analyze MRI scans, called activity MRI (aMRI), to see if it can provide the same information about brain tumor activity as a standard PET scan. Researchers will compare the two scans in 20 adults with glioma to see if the new MRI method is a val…

This study is testing whether a new type of brain scan can help doctors better see how well treatments are working for children and young adults with low-grade brain tumors. Participants will get the special scan before starting treatment and again at 3 months and 1 year. Researc…

This study is testing a new type of MRI scan to see if it can help doctors better diagnose brain tumors called gliomas. Up to 5 adults with suspected or known gliomas will receive the new scan to check its safety and accuracy. Researchers will compare the new scan's results to st…

This study is testing a new, faster type of MRI scan to help doctors tell the difference between a brain tumor that has come back and damage caused by previous radiation treatment. Currently, this often requires risky brain surgery to confirm. The research involves 60 people, inc…

This study is testing a new support program designed to help people cope after being diagnosed with a malignant brain tumor. Participants will receive a guide and one-on-one coaching sessions. The main goal is to see if patients find the program helpful and are able to complete i…

This study aims to understand why some patients with a type of brain tumor called glioma develop severe drops in blood cell counts when taking the chemotherapy drug temozolomide. Researchers will analyze blood, genes, and gut bacteria from about 55 patients to identify factors th…

This study aims to understand if platelets, tiny blood cells, are present inside brain tumors and if their presence is linked to how long patients live. Researchers will collect and analyze tumor tissue and blood samples from 50 adults undergoing surgery for brain or spinal cord …

This study aims to understand how the cancer drug olutasidenib affects how the body processes other medications. Researchers will measure blood levels of several test drugs in 16 adult patients with specific genetic mutations in their cancers. The goal is to learn about potential…

This study is testing whether advanced MRI scans can better identify which areas of a malignant brain tumor are most likely to grow back after standard treatment. Researchers will enroll adults with glioma to see if these detailed images can safely help guide future radiation the…

This study is building a large database of information from people with brain tumors. It will collect brain scans, treatment details, and health outcomes from up to 70,000 participants. The goal is to use this data to create better tools for predicting how tumors behave and how p…

This study aims to understand how vision and attention problems change over time in patients with brain tumors in the parietal lobe. Researchers will follow 40 patients before and after their tumor removal surgery, using simple paper-and-pencil tests to measure these difficulties…

This study is testing whether an early telehealth visit can help patients newly diagnosed with a fast-growing brain tumor discuss and document their end-of-life care wishes. The goal is to see if this structured conversation, done soon after diagnosis, improves the patient's expe…

This study is testing a new type of ultra-thin, flexible brain mapping electrode made from graphene material during brain tumor surgery. Researchers want to see if these new electrodes are safe to use and if they can record clearer brain signals than current devices. Ten patients…

This study aims to understand why many childhood cancer survivors continue to experience groups of symptoms like fatigue, pain, and depression. Researchers will follow 600 survivors and their caregivers, collecting surveys and stool samples over time. The goal is to see if change…

This study is testing a tiny catheter placed during brain surgery to collect fluid from the tumor area. The goal is to find chemical markers in the fluid that could help doctors better understand, diagnose, and monitor brain tumors in the future. The procedure is done during a pa…

This study analyzes cancer patients' tumor tissue and blood samples to identify specific genetic changes in their cancer. The goal is to create a detailed database of cancer mutations and use that information to match patients with the most relevant treatment options and clinical…

This early-phase study is testing whether a new radioactive tracer, called Zr-89 crefmirlimab berdoxam, can help doctors see immune cells inside brain tumors using a PET scan. The goal is to see if this non-invasive scan can accurately show where immune cells are active, which co…

This study aims to understand how radiation therapy for brain tumors affects patients' thinking and memory skills. Researchers will use special brain scans and memory tests before and after treatment to identify which brain networks are most vulnerable to radiation damage. The fi…

This study is investigating whether measuring the stiffness and stickiness of brain tumors using a special MRI technique can help doctors better understand tumor characteristics. Researchers will scan 100 adults with glioma before surgery, then compare scan results with surgical …

This study aims to learn if advanced brain scans (MRI and PET) can predict genetic mutations in brain tumors called gliomas. Researchers will enroll 20 adults with a glioma who are scheduled for a tumor biopsy. They will compare detailed scan images with genetic data from the act…

This study is collecting information on people with various types of brain tumors to see if a new, more detailed way of classifying them helps doctors choose better treatments and predict outcomes more accurately. It will follow about 1,650 patients for up to five years to compar…

This study aims to understand how often a protective fluid around the brain leaks after surgery to remove a brain tumor. Researchers will follow 200 adult patients to see who develops a leak, identify what factors make it more likely, and track how doctors manage it. The goal is …

This study is testing a new mobile app called 'Iskhaa' that allows people with brain tumors to check their own neurological function at home. Participants record videos of themselves doing simple tasks like walking and speaking, which an artificial intelligence (AI) program then …

This study aims to build a UK-wide network to provide faster and more precise genetic diagnosis for people with glioma brain tumors. By analyzing tumor tissue from 1,000 patients, researchers will create the infrastructure needed to quickly launch future trials of personalized tr…