Brain tumor genetics revealed by noninvasive scan

NCT ID NCT05700071

Recruiting now Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study tests whether advanced MRI and magnetic resonance spectroscopy (MRS) can identify specific genetic mutations in gliomas, the most common type of brain tumor. Researchers will scan about 110 people with suspected or confirmed low- or high-grade gliomas before surgery or treatment. The goal is to see if chemical markers like 2-hydroxyglutarate and cystathionine can reliably indicate IDH mutations and 1p/19q codeletions, potentially reducing the need for invasive biopsies and helping tailor treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could enable noninvasive detection of key genetic mutations in brain tumors, guiding treatment decisions without surgery.
What could go wrong: This is an observational study, not a treatment trial. The techniques may not prove reliable enough for routine clinical use.

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Conditions

The condition(s) this trial relates to.

disease glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris
RECRUITING

Paris, Île-de-France Region, 75013, France

Contact Phone: •••-•••-•••• Email: •••••@•••••
Pitié-Salpetrière Hospital
NOT_YET_RECRUITING

Paris, 75013, France

Contact Phone: •••-•••-•••• Email: •••••@•••••

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