Can scans predict brain tumor mutations?

NCT ID NCT05386043

Recruiting now Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how brain tumors (gliomas) change over time and whether advanced MRI and PET scans can predict those changes. Twenty adults with suspected glioma will have special scans before surgery, and their tumor tissue will be analyzed. The goal is to see if imaging can replace repeated biopsies to track tumor mutations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FET F-18, O-15 Radioisotope
What this could lead to: If successful, this could lead to better ways to predict tumor mutations using non-invasive scans, potentially guiding treatment without repeated biopsies.
What could go wrong: This is a small, early-stage study with only 20 participants, so results may not apply broadly. The imaging techniques are experimental and may not reliably predict mutations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOMA

Contacts and locations

Locations

Indiana University School of Medicine
RECRUITING

Indianapolis, Indiana, 46202, United States

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