GLIOMA

This early-phase study tested two experimental drugs, AG-120 and AG-881, in 49 adults with a recurrent low-grade glioma that has a specific genetic change (IDH1 mutation). The main goal was to see how well the drugs lower a substance called 2-HG in the tumor tissue after a short …

This study tested a drug called VAL-083 combined with standard radiation for people newly diagnosed with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to find a safe dose and see if the combination helps control th…

This study tested whether a device called ExAblate can safely and repeatedly open the blood-brain barrier in 20 adults with high-grade glioma (a serious brain cancer) who were already receiving standard chemotherapy. The goal was to allow chemotherapy drugs to better reach the tu…

This early-phase trial tested an oral drug called AG-881 in 95 adults with advanced gliomas (a type of brain tumor) that have an IDH1 or IDH2 mutation. The main goals were to check the drug's safety, find the best dose, and see if it shrinks tumors. The study was completed, but b…

This study tested a mix of two drugs (retifanlimab and epacadostat) plus radiation and bevacizumab in 51 people with recurrent glioblastoma, a serious brain cancer. The goal was to see if this combination could help the immune system fight the tumor and improve survival. While th…

This early-phase study tested a new treatment for children and young adults with brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein called EGFR fou…

This small pilot study tested a device called NaviFUS that uses focused ultrasound waves, combined with the standard drug bevacizumab, in 6 adults whose glioblastoma brain tumor had returned after prior treatment. The goal was to see if the combination was safe and could help con…

This early-phase study tested an oral drug called AG-120 in 174 people with advanced solid tumors (including bile duct cancer, cartilage cancer, and brain tumors) that have a specific IDH1 gene mutation. The goal was to find the safest dose and see how the drug works in the body.…

This early-phase study tested a combination of two drugs, Fluvastatin and Celebrex, in 20 children and young adults with certain types of brain tumors (gliomas) that had come back or not responded to standard treatments. The main goal was to find the safest dose of Fluvastatin wh…

This study tested a new MRI contrast agent called RVP-001, which does not contain gadolinium, in 18 adults with brain lesions from conditions like tumors or multiple sclerosis. The goal was to see if it is safe and effective at highlighting these lesions compared to standard gado…

This study looked at whether a special PET scan using 18F-FDOPA can help doctors decide on the best treatment for people with brain tumors (gliomas or metastases) when MRI results are unclear. 85 patients were enrolled. The goal was to see if the PET scan increased doctors' confi…

This study looked at how people with brain tumors or breast cancer perceive their own memory, especially the ability to remember to do things in the future (like taking medication). Over 400 participants completed questionnaires about memory, mood, and fatigue. The goal was to un…

This study looked at whether video doctor visits work as well as in-person visits for people with brain tumors (gliomas) who are taking oral chemotherapy. 30 patients took part, alternating between telehealth and in-person checkups. The goal was to see which type of visit patient…

This study looked at how chemotherapy (temozolomide) affects quality of life and thinking skills in 26 adults with a slow-growing brain tumor called low-grade glioma. Researchers measured how many patients agreed to join and how many completed surveys over 12 months. The goal is …

This study tested whether combining PET/MRI scans with machine learning can more accurately identify how aggressive solid tumors are. Researchers scanned 49 adults with prostate cancer, liver cancer, kidney cancer, or brain tumors. The goal was to improve diagnosis, not to treat …

This small pilot study looked at whether a new type of MRI, called Field Cycling Imaging (FCI), can tell apart different subtypes of low grade gliomas in people who have already had surgery. Nine participants each received one FCI scan. The goal was to see if this non-invasive te…

This study tested an experimental drug called AB-218 in 14 people with a specific type of slow-growing brain tumor (IDH1 mutated low-grade glioma) who were already scheduled for surgery. The main goals were to see if it's possible to run this kind of study and to measure how much…

This study looked at how well two drugs, LY3214996 and abemaciclib, get into the brain tumors of people with recurrent glioblastoma. About 42 participants took the drugs before surgery to remove their tumor. Researchers measured drug levels in the tumor tissue and spinal fluid to…

This study looked at whether it's possible to use a child's tumor DNA to choose their next treatment. 186 children with cancers that came back or didn't respond to standard therapy had their tumors analyzed. The goal was to see if this approach could be done quickly enough to gui…

This study looked at 44 people with a type of brain tumor called glioma. Researchers used a special brain scan (fMRI) to see if the swollen tissue around the tumor still worked. They then took small tissue samples during surgery to check if the scan results matched what was seen …