GLIOMA

This early-phase study tested a personalized cell therapy for children and young adults with recurrent or hard-to-treat brain tumors. Doctors collected patients' own immune cells, engineered them in a lab to target a specific protein (EGFR) on the tumor, and then delivered these …

This study tested a drug called VAL-083, given alongside standard radiation therapy, for people newly diagnosed with an aggressive brain cancer called glioblastoma (GBM). It focused on patients whose tumors have a specific genetic feature (unmethylated MGMT) that makes them less …

This study tested whether a focused ultrasound device called ExAblate could safely and temporarily open the blood-brain barrier—a natural protective layer—in patients with aggressive brain tumors (glioblastoma). The goal was to see if opening this barrier could help standard chem…

This study tested a combination of four treatments for patients whose aggressive brain cancer (glioblastoma) had returned. The goal was to see if using two immunotherapy drugs alongside radiation and a targeted therapy could help the immune system fight the cancer better, shrink …

This study tested a drug called AB-218 (Safusidenib) in patients with a specific genetic type of slow-growing brain tumor (IDH1 mutated low-grade glioma). The main goal was to see if it was practical to give the drug before planned surgery and to measure how much of the drug reac…

This early-stage study tested a new oral drug, AG-881, in adults with advanced solid tumors, including a type of brain tumor called glioma, that have specific IDH gene mutations. The main goals were to find a safe dose and see how the body processes the drug. Researchers enrolled…

This early-stage study aimed to find the safest dose of a two-drug combination (Fluvastatin and Celebrex) for children and young adults whose brain tumors had come back or stopped responding to standard treatments. The trial involved 20 participants across multiple French hospita…

This first-in-human study tested a new oral drug, AG-120, designed to target a specific genetic flaw (IDH1 mutation) found in several advanced solid tumors, including certain brain, bile duct, and bone cancers. The main goals were to find the safest and most effective dose and to…

This study tested if two oral drugs, LY3214996 and abemaciclib, could reach brain tumors in people with recurrent glioblastoma. Up to 50 adults scheduled for surgery took the drugs before their operation so researchers could measure drug levels in the tumor tissue. The main goals…

This study tested a new MRI contrast agent called RVP-001, which uses manganese instead of gadolinium, to see if it could safely and effectively detect lesions in the brain and central nervous system. It involved 18 adults with known conditions like brain tumors or multiple scler…

This study investigated whether a special type of brain scan (resting-state fMRI) could identify which areas of swollen tissue around a brain tumor are still healthy and functioning. Researchers scanned 44 adults with glioma before their scheduled surgery and then analyzed tiny t…

This study aimed to understand how a chemotherapy drug called temozolomide (TMZ) affects the thinking skills and quality of life of adults with a specific slow-growing brain tumor (diffuse low-grade glioma). Researchers followed 26 patients over a year to measure changes in memor…

This early-stage study tested two drugs, AG-120 and AG-881, in adults with a recurring, slow-growing brain tumor that has a specific genetic change (IDH1 mutation). The main goal was to see if taking one of these drugs before planned surgery could lower levels of a harmful chemic…

This study aimed to find out if brain tumor (glioma) patients receiving oral chemotherapy at home were as satisfied with remote video visits (telehealth) as with traditional in-person clinic visits. It involved 30 patients who alternated between telehealth and in-person check-ups…

This study tested whether doctors could quickly analyze the genetic makeup of a child's tumor and use that information to choose a personalized treatment plan. It involved 186 children and young adults (up to age 21) whose cancers had returned or did not respond to standard treat…

This study aimed to understand the nature of memory complaints in people with cancer, specifically brain tumors or breast cancer. Researchers compared 426 participants, including patients and healthy controls, to see if they reported more issues with remembering future plans (pro…