Engineered immune cells delivered directly to the brain show promise in kids with tough tumors

This early-phase study tested a new treatment for children and young adults with brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein called EGFR found on the tumor cells. These modified cells are delivered directly into the brain through a small tube. The main goals were to see if this approach is safe and possible to do, and to learn how the cells behave in the body.