Immune cells injected directly into brain show promise for kids with tough tumors

NCT ID NCT03638167

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-stage study tested a new treatment for children and young adults with brain tumors that came back or didn't respond to standard therapy. Doctors took the patients' own immune cells, modified them to recognize a protein called EGFR on tumor cells, and injected them directly into the brain. The goal was to see if this approach is safe and possible, and to measure how the cells spread and work against the tumors.

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Conditions

The condition(s) this trial relates to.

atypical teratoid rhabdoid tumor brain cancer central nervous system cancer choroid plexus carcinoma ependymoma germ cell tumor glioma medulloblastoma Neoplasms, Germ Cell and Embryonal Neuroectodermal Tumors, Primitive Pinealoma pineoblastoma primitive neuroectodermal tumor rhabdoid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States