Seattle Children's Hospital

This study tests whether feeding babies with congenital gastrointestinal issues (like gastroschisis or Hirschsprung disease) only human milk helps them reach full feeds faster than standard care, which may include formula. Researchers will also look at gut bacteria and infection …

This early-phase study tests whether a new type of immunotherapy, called B7-H3 CAR T cells, can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG, DMG, or other recurrent central nervous system cancers. The…

This early-stage trial tests a new type of immunotherapy for children and young adults with solid tumors that have not responded to standard treatments. The therapy uses the patient's own immune cells, which are genetically modified in the lab to recognize and attack cancer cells…

This early-stage study tests a new treatment called SC-DARIC33 for children and young adults up to age 30 whose acute myeloid leukemia (AML) has returned or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in the lab to bett…

This early-stage trial tests a new treatment for children and young adults (ages 2-30) with severe lupus that hasn't responded to standard therapies. The treatment involves collecting a patient's own immune cells, engineering them to target and destroy faulty B cells (which drive…

This study tests an online program called REACH for parents who have irritable bowel syndrome (IBS). The goal is to see if the program can help parents encourage healthy habits in their young children and reduce the chance of the kids developing similar stomach problems. About 46…

This pilot study tests a communication tool for parents of children with severe neurological problems in the intensive care unit. Parents pick 1-3 photos that show what matters to their family and share them with doctors. The goal is to see if this approach is practical, acceptab…

This study tests an internet-delivered pain self-management program for adults with chronic pancreatitis who suffer from severe abdominal pain. The program uses psychological techniques to help reduce pain's impact on daily life and improve quality of life. Researchers aim to enr…

This study tests a bilingual program called 1stBIEN for Hispanic children (ages 3-17) recovering from traumatic brain injury. The program provides in-person education, mobile videos, and a navigator to help families access outpatient care and school support. Researchers will meas…

This study compares two non-drug treatments for teens aged 13-17 with ADHD: Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI). Both involve eight 90-minute sessions. Researchers will measure changes in ADHD symptoms, daily functioning, and emotional co…

This pilot study tests a new program called CRISP to help young adults aged 18-29 recover from concussion and manage headaches. The program focuses on support and recovery strategies. Researchers will measure how acceptable the treatment is and track changes in headache severity …

This study follows up to 500 people who have received a gene therapy product from Seattle Children's Hospital. Researchers will track participants for 15 years to watch for any delayed side effects and see how long the therapy lasts in the body. No new treatment is given—this is …

This study compares a redesigned well-child care approach, where a community health worker (called a 'Parent's Coach') helps deliver checkup services, to traditional care for Black families. The goal is to see if this team-based model improves receipt of preventive services, redu…

This study tests a new tool called the Family Media Check-In that helps parents and teens work together to create a family media plan. About 300 parent-teen pairs will try it and report how satisfied they are with the plan and how much conflict it reduces. The goal is to see if s…

This study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) or other gut disorders. Researchers will use a cutting-edge technique called spatial transcriptomics to map gene activity directly inside gut tissue. The goal is to better…

This study looks at two different approaches to help doctors and families avoid unnecessary follow-up visits after a child is hospitalized for bronchiolitis. About 2,700 children will take part to see which method works better at encouraging follow-up only when needed. The goal i…

This study looks at which treatments work best to prevent suicide in teens aged 11 to 17 who have been hospitalized for suicidal thoughts or actions. Researchers will compare different intervention strategies to see which ones reduce suicide attempts and related crises. The goal …