Seattle Children's Hospital

This early-phase trial tests whether a child's own immune cells, genetically modified to recognize and attack leukemia cells, are safe and can be given in the right dose. Six children and young adults with CD19-positive acute lymphoblastic leukemia that has returned after treatme…

This pilot study tests whether giving special immune cells called T-APCs after CAR T cell therapy can help the CAR T cells persist longer in the body and prevent leukemia from returning. It involves 30 children and young adults with relapsed or refractory CD19+ leukemia who have …

This early-stage trial tests a new approach for children and young adults with neuroblastoma that has come back or not responded to standard treatments. Doctors take a patient's own immune cells (T-cells), genetically modify them in the lab to recognize and attack a protein calle…

This early-phase study tests a personalized cell therapy for children and young adults (up to age 26) with solid tumors that have come back or not responded to standard treatment. The therapy uses the patient's own immune cells, modified to recognize and attack a protein called B…

This study tests a new treatment for children and young adults up to age 30 whose leukemia or lymphoma has come back or not responded to standard therapy. The treatment uses the patient's own immune cells (T cells) that are genetically modified in a lab to recognize and attack ca…

This study tests whether adding a weekly injection of exenatide (Bydureon) to family-based behavioral treatment helps children aged 10-12 with obesity lose weight more effectively. The trial involves 63 children and their parents, with weekly sessions over 24 weeks. Researchers w…

This early-phase study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The therapy a…

This early-phase study tests a new type of immunotherapy for children and young adults with leukemia that has come back or not responded to treatment. The therapy uses the patient's own immune cells, modified to recognize two different targets (CD19 and CD22) on leukemia cells, t…

This early-stage trial tests a new treatment called SC-CAR4BRAIN for children and young adults with certain aggressive brain tumors, including DIPG and DMG. The treatment involves taking a patient's own immune T cells, engineering them in a lab to recognize and attack tumor cells…

This early-stage trial tests a new type of immunotherapy for children and young adults with solid tumors that have not responded to standard treatments. The therapy uses the patient's own immune cells (T cells) that are genetically modified to recognize and attack cancer cells ca…

This early-phase trial tests a two-part treatment for osteosarcoma that has come back or not responded to standard care. First, a patient's own T cells are collected and genetically modified to become CAR T cells that can recognize a special flag. Then, after some chemotherapy, t…

This study aimed to see if a telehealth skills group could help middle and high school students with ADHD improve their organization, motivation, and grades. Both the treatment and control groups were delivered via Zoom. However, the study was withdrawn before enrolling any parti…

This study tests the Family Bridge Program, which uses a trained guide to help low-income families navigate the hospital, communicate with doctors, and prepare for going home. About 728 families with children in the hospital will be randomly assigned to get the program or usual c…

This study looks at whether giving doctors training and mobile video interpretation tools helps them communicate better with patients who have limited English. Over 6,600 patients and their doctors are taking part. The goal is to see if these tools increase the use of professiona…