Could a weekly shot help kids with obesity? new trial tests combo therapy

NCT ID NCT04520490

Ongoing Disease control Sponsor: Seattle Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a weekly injection of exenatide (Bydureon) to family-based behavioral treatment helps children aged 10-12 with obesity lose weight more effectively. The trial involves 63 children and their parents, with weekly sessions over 24 weeks. Researchers will measure changes in body mass index (BMI) and body composition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exenatide (Bydureon) once weekly injection
What this could lead to: If successful, this combination approach could offer a more effective way to help children with obesity achieve lasting weight control.
What could go wrong: This is a small, early-phase study (63 participants) and results may not apply to all children. The drug exenatide can cause side effects like nausea, and long-term safety in children is not yet established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obesity disorder Pediatric Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILDHOOD OBESITY

Contacts and locations

Locations

Seattle Children's Hospital

Seattle, Washington, 98105, United States

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Other studies related to the condition(s) this trial covers.