Seattle Children's Hospital

This early-stage trial tests a new treatment for adults with solid tumors that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells that carry a protein called GPC3. The…

This study tests a website called Family Safety Check-In that helps families with children decide how to store their firearms more safely. About 548 parents or guardians who have guns at home and currently store them unsafely will be randomly assigned to use the website or read a…

This study tests whether a simple pre-game safety huddle—where coaches, referees, and players briefly talk about the importance of reporting concussion symptoms—can improve concussion reporting in youth soccer. Researchers will enroll 2,000 children aged 9-13 and their coaches ac…

This study looks at whether using clear, non-blood fluids to fill the heart-lung machine during surgery can reduce inflammation in infants having a hole in the heart repaired. Sixty babies aged 1 to 18 months will be enrolled. Researchers will measure inflammation markers and rec…

This study will enroll 200 children with cystic fibrosis (100 Hispanic, 100 non-Hispanic white) to measure indoor and outdoor air pollution and see how it relates to lung function, inflammation, and airway bacteria. Researchers hope to understand why Hispanic children often have …

This study looks at how two types of birth control devices—copper IUDs and hormonal IUDs—affect the bacteria in the vagina and the risk of infections. About 120 HIV-negative women aged 18-40 will be randomly assigned to one device and followed for a year. Researchers will collect…

This study tests a training program called PIVOT-IN that teaches hospital doctors and nurses how to talk with families about childhood vaccines. The goal is to see if this training helps more kids get the vaccines they need while they are in the hospital. About 2,000 children and…