Could clear priming reduce inflammation after infant heart surgery?

NCT ID NCT07393243

Not yet recruiting Symptom relief Sponsor: Seattle Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether using clear, non-blood fluids to fill the heart-lung machine during surgery can reduce inflammation in infants having a hole in the heart repaired. Sixty babies aged 1 to 18 months will be enrolled. Researchers will measure inflammation markers and recovery times to see if the clear priming method is better than using donated blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: non-blood priming fluid
What this could lead to: If it works, this could lead to a safer way to perform heart surgery in infants, reducing inflammation and speeding recovery.
What could go wrong: This is a small, early-stage study with only 60 participants, so results may not apply to all children. The non-blood prime may not reduce inflammation as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation ventricular septal defect

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENTRICULAR SEPTAL DEFECT

Contacts and locations

Locations

Seattle Children's Hospital

Seattle, Washington, 98115, United States

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